The release of cathepsin proteases from disrupted lysosomes results in lethal cellular autodigestion. Lysosomal disruption-related cell death is highly variable, showing both apoptotic and necrotic ...

There are 11 human cysteine cathepsins, which primarily function as endopeptidases within endolysosomal compartments. Specific cysteine cathepsins have extracellular functions, for example, cathepsin ...

Cathepsins are enzymes (known as proteases) that break down proteins. They play an important role in cell turnover, which is the process by which cells are replaced by young cells when older cells die ...