Researchers from the National University of Singapore (NUS) have solved a 60-year-old mystery in bacterial cell envelope biology, defining the primary function of an important protein complex ...

The discovery and clinical utilization of antimicrobials was a very significant turning point in the history of medicine, which significantly reduced morbidity and mortality worldwide. However, this ...

Researchers have developed a new antibiotic that reduced or eliminated drug-resistant bacterial infections in mouse models of acute pneumonia and sepsis, while sparing healthy microbes in the mouse ...

Gram-positive bacteria show blue or purple after Gram-staining in a laboratory test. They have thick cell walls. Gram-negative bacteria show pink or red on staining and have thin walls. They release ...

A team led by Paul Hergenrother at the University of Illinois Urbana-Champaign has discovered a new antibiotic that exclusively targets gram-negative bacteria and avoids wiping out the ecosystem of ...

The Tol-Pal complex maintains bacterial outer membrane (OM) stability by regulating lipid homeostasis. (Left) In Gram-negative bacteria, the OM acts as a protective barrier, blocking entry of harmful ...

A new study published in Nature today has identified a potential Achilles heel in the protective layers surrounding Gram-negative bacteria that could aid in the development of next-generation ...

Gram-negative meningitis is a form of meningitis. The term gram-negative refers to a way of differentiating bacteria. This type of bacteria is typically resistant to drugs and most available ...

Comparing the activity of each compound across the three variants allowed us to gain insight into the balance of the two major factors underpinning low drug uptake in GN organisms, active efflux and ...

• Require X (hemin) and/or V (nicotinamide adenine dinucleotide) factors for growth • Responsible for 0.5–1% of all cases of IE • Haemophilus aphrophilus is the most common species responsible for IE ...